Study of Formulation Variables Influencing Polymeric Microparticles by Experimental Design

Study of formulation variables influencing polymeric microparticles by experimental design

The objective of this study was to prepare diclofenac sodium loaded microparticles using the single emulsion [oil-in-water (o/w)] solvent evaporation method. The 2 2 experimental design methodology was using the Design-Expert ® software used to evaluate the effect of two formulation variables on the properties of the microspheres in terms of particle size, morphology, encapsulation efficiency, ...

application of statistical experimental design and artificial neural networks to study the formulation variables influencing the characteristics of cefixime tablet

Theophylline-Ethylcellulose Microparticles: Screening of the Process and Formulation Variables for Preparation of Sustained Release Particles

Objective(s) The aim of this study was to formulate and evaluate microencapsulated controlled release preparations of theophylline using ethylcellulose as the retardant material with high entrapment efficiency. Materials and Methods Microspheres were prepared by water-in-oil-in-oil (W/O1/O2) emulsion-solvent diffusion (ESD). A mixed solvent system consisting of acetonitrile and dichloromet...

hydrochlorothiazide detection in urine samples by hplc-dad and experimental design dispersive l-l microextraction

hydrochlorothiazide (hct) is a diuretic agent which is shown to be effective in the treatment of hypertension. literature reports have demonstrated that urinary excretion data may be used to assess the bioavailability of various formulations containing this thiazide. also hct consumption by the athletes is one of the drugs which should be regulated by world anti-doping agency (wada), because of...

Optimization of a Waterborne Epoxy Coatings Formulation via Experimental Design

Waterborne Epoxy based coatings were prepared by using a water-borne epoxy resin and a suitable hardener. The formulation and optimization procedure were carried out on the bases of experimental designs by the mixture design technique in which the important paint properties are modeled by using special cubic model. The corrosion behavior of these coatings was investigated using electrochemical ...